Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2208026..2208669 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag MR259_RS10195 Protein ID WP_003401566.1
Coordinates 2208244..2208669 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag MR259_RS10190 Protein ID WP_003401563.1
Coordinates 2208026..2208247 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS10165 2203145..2203948 - 804 WP_003401540.1 Stf0 family sulphotransferase -
MR259_RS10170 2203958..2205355 - 1398 WP_003401544.1 sulfatase -
MR259_RS10175 2205534..2207309 + 1776 WP_010886074.1 PE family protein -
MR259_RS10180 2207452..2207679 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
MR259_RS10185 2207676..2207978 + 303 WP_003401560.1 toxin-antitoxin system toxin -
MR259_RS10190 2208026..2208247 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
MR259_RS10195 2208244..2208669 + 426 WP_003401566.1 PIN domain nuclease Toxin
MR259_RS10200 2208805..2209437 + 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
MR259_RS10205 2209434..2210342 + 909 WP_003900117.1 protochlorophyllide reductase -
MR259_RS10210 2210350..2210940 - 591 WP_229298012.1 hypothetical protein -
MR259_RS10215 2210933..2210983 - 51 Protein_2017 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T295163 WP_003401566.1 NZ_OW052189:2208244-2208669 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT295163 WP_003401563.1 NZ_OW052189:2208026-2208247 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References