Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1918906..1919539 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFC0
Locus tag MR259_RS08980 Protein ID WP_003400580.1
Coordinates 1919138..1919539 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P0CW29
Locus tag MR259_RS08975 Protein ID WP_003400577.1
Coordinates 1918906..1919145 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS08960 1914202..1915642 + 1441 Protein_1766 FAD-binding oxidoreductase -
MR259_RS08965 1915698..1915859 + 162 WP_003899796.1 hypothetical protein -
MR259_RS08970 1915900..1918839 + 2940 WP_003901785.1 UPF0182 family protein -
MR259_RS08975 1918906..1919145 + 240 WP_003400577.1 antitoxin VapB1 Antitoxin
MR259_RS08980 1919138..1919539 + 402 WP_003400580.1 type II toxin-antitoxin system ribonuclease VapC1 Toxin
MR259_RS08985 1919591..1921828 - 2238 WP_003899797.1 NADP-dependent isocitrate dehydrogenase -
MR259_RS08990 1921946..1922515 - 570 WP_003400591.1 TetR/AcrR family transcriptional regulator -
MR259_RS08995 1922618..1923529 + 912 WP_003899798.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(36-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.44 Da        Isoelectric Point: 4.8887

>T295160 WP_003400580.1 NZ_OW052189:1919138-1919539 [Mycobacterium tuberculosis]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Download         Length: 402 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8717.84 Da        Isoelectric Point: 8.5960

>AT295160 WP_003400577.1 NZ_OW052189:1918906-1919145 [Mycobacterium tuberculosis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEAIEILEQALASTASPGISRETIEASRRELRGG

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BR82

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHM7

References