Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 1199911..1200440 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag MR259_RS05645 Protein ID WP_003417760.1
Coordinates 1200183..1200440 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag MR259_RS05640 Protein ID WP_003417757.1
Coordinates 1199911..1200186 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS05605 1196484..1197173 - 690 WP_003917774.1 BBE domain-containing protein -
MR259_RS05610 1197360..1197731 - 372 WP_003417739.1 FAD-binding protein -
MR259_RS05615 1197629..1197847 - 219 WP_157132559.1 hypothetical protein -
MR259_RS05620 1197874..1198134 - 261 WP_003417741.1 hypothetical protein -
MR259_RS05625 1198249..1198638 + 390 WP_003417745.1 DUF732 domain-containing protein -
MR259_RS05630 1198652..1198945 - 294 WP_003417749.1 DUF3017 domain-containing protein -
MR259_RS05635 1198942..1199787 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
MR259_RS05640 1199911..1200186 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
MR259_RS05645 1200183..1200440 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
MR259_RS05650 1200482..1201672 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
MR259_RS05655 1201789..1202157 + 369 WP_003417765.1 FHA domain-containing protein -
MR259_RS05660 1202154..1202705 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
MR259_RS05665 1202712..1203293 - 582 WP_003417769.1 ATP/GTP-binding protein -
MR259_RS05670 1203274..1203642 - 369 WP_003417772.1 DUF742 domain-containing protein -
MR259_RS05675 1203620..1204012 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T295157 WP_003417760.1 NZ_OW052189:1200183-1200440 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT295157 WP_003417757.1 NZ_OW052189:1199911-1200186 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References