Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 601093..601780 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag MR259_RS03040 Protein ID WP_003414624.1
Coordinates 601337..601780 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag MR259_RS03035 Protein ID WP_003414620.1
Coordinates 601093..601350 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS03015 596413..597267 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
MR259_RS03020 597323..598486 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MR259_RS03025 598503..599717 - 1215 WP_003414610.1 zinc metalloprotease Rip -
MR259_RS03030 599725..600966 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
MR259_RS03035 601093..601350 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
MR259_RS03040 601337..601780 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
MR259_RS03045 601860..602522 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
MR259_RS03050 602618..602809 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
MR259_RS03055 603141..604889 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
MR259_RS03060 604985..605566 + 582 WP_003414644.1 fasciclin domain-containing protein -
MR259_RS03065 605666..605932 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T295154 WP_003414624.1 NZ_OW052189:601337-601780 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT295154 WP_003414620.1 NZ_OW052189:601093-601350 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References