Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 534377..534947 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag MR259_RS02690 Protein ID WP_003414166.1
Coordinates 534377..534733 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag MR259_RS02695 Protein ID WP_003901465.1
Coordinates 534717..534947 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS02670 529832..531520 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
MR259_RS02675 531524..531850 - 327 WP_003414157.1 hypothetical protein -
MR259_RS02680 532023..532607 + 585 WP_031705940.1 DUF3558 family protein -
MR259_RS02685 532626..534275 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
MR259_RS02690 534377..534733 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
MR259_RS02695 534717..534947 - 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
MR259_RS02700 534990..536033 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
MR259_RS02705 536032..536499 + 468 WP_003414177.1 DUF1778 domain-containing protein -
MR259_RS02710 536675..536929 - 255 WP_003917684.1 hypothetical protein -
MR259_RS02715 537077..537481 + 405 WP_003414181.1 hypothetical protein -
MR259_RS02720 537478..537669 + 192 WP_003414184.1 hypothetical protein -
MR259_RS02725 537886..538146 + 261 Protein_533 transposase -
MR259_RS02730 539256..539513 + 258 WP_003899489.1 hypothetical protein -
MR259_RS02735 539618..539929 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T295150 WP_003414166.1 NZ_OW052189:c534733-534377 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT295150 WP_003901465.1 NZ_OW052189:c534947-534717 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References