295146

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 355396..356110 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag MR259_RS01635 Protein ID WP_003413460.1
Coordinates 355670..356110 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag MR259_RS01630 Protein ID WP_003413456.1
Coordinates 355396..355683 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS01595 350818..351063 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MR259_RS01600 351060..351464 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
MR259_RS01605 351681..352301 + 621 WP_003413441.1 DUF4178 domain-containing protein -
MR259_RS01610 352312..352806 + 495 WP_003413444.1 DUF2617 family protein -
MR259_RS01615 352803..353234 + 432 WP_003899390.1 DUF4247 domain-containing protein -
MR259_RS01620 353259..353717 + 459 WP_003413451.1 DUF350 domain-containing protein -
MR259_RS01625 353714..355285 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
MR259_RS01630 355396..355683 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
MR259_RS01635 355670..356110 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
MR259_RS01640 356131..356886 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
MR259_RS01645 357019..357615 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
MR259_RS01650 357623..358468 - 846 WP_003413466.1 acyl-CoA thioesterase II -
MR259_RS01655 358497..359396 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
MR259_RS01660 359524..360198 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T295146 WP_003413460.1 NZ_OW052189:355670-356110 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT295146 WP_003413456.1 NZ_OW052189:355396-355683 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References