Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 295054..295691 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag MR259_RS01370 Protein ID WP_003413180.1
Coordinates 295054..295449 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag MR259_RS01375 Protein ID WP_003413183.1
Coordinates 295446..295691 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS01330 290458..291669 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
MR259_RS01335 291796..292455 + 660 WP_003902296.1 LppA family lipoprotein -
MR259_RS01340 292452..293114 + 663 WP_003905878.1 LppA family lipoprotein -
MR259_RS01345 293111..293388 + 278 Protein_262 type II toxin-antitoxin system VapB family antitoxin -
MR259_RS01350 293481..293894 + 414 WP_003413164.1 PIN domain nuclease -
MR259_RS01355 293933..294190 + 258 WP_003413167.1 CopG family transcriptional regulator -
MR259_RS01360 294187..294564 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
MR259_RS01365 294580..294954 - 375 WP_003413177.1 hypothetical protein -
MR259_RS01370 295054..295449 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
MR259_RS01375 295446..295691 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
MR259_RS01380 296102..296521 - 420 WP_003413190.1 A24 family peptidase -
MR259_RS01385 296533..297342 - 810 WP_003413193.1 shikimate dehydrogenase -
MR259_RS01390 297339..298592 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
MR259_RS01395 298585..299097 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T295145 WP_003413180.1 NZ_OW052189:c295449-295054 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT295145 WP_003413183.1 NZ_OW052189:c295691-295446 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References