295140

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 4357325..4358375 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name phRel Uniprot ID -
Locus tag MR221_RS20340 Protein ID WP_242363193.1
Coordinates 4357554..4358375 (-) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag MR221_RS20335 Protein ID WP_003407167.1
Coordinates 4357325..4357561 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS20320 4353295..4354764 - 1470 WP_003900326.1 cytochrome b5 domain-containing protein -
MR221_RS20325 4354960..4355745 - 786 WP_003407180.1 lipoprotein LprF -
MR221_RS20330 4356048..4357253 + 1206 WP_003918234.1 serine hydrolase domain-containing protein -
MR221_RS20335 4357325..4357561 - 237 WP_003407167.1 hypothetical protein Antitoxin
MR221_RS20340 4357554..4358375 - 822 WP_242363193.1 GTP pyrophosphokinase family protein Toxin
MR221_RS20345 4358596..4358982 + 387 WP_003904611.1 anti-sigma-F factor antagonist RsfA -
MR221_RS20350 4359121..4361082 + 1962 WP_003407159.1 sigma-F factor regulator -
MR221_RS20355 4361373..4362158 + 786 WP_003407157.1 membrane protein -
MR221_RS20360 4362155..4362817 + 663 WP_003407152.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30086.03 Da        Isoelectric Point: 5.5817

>T295140 WP_242363193.1 NZ_OW052188:c4358375-4357554 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNNATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT295140 WP_003407167.1 NZ_OW052188:c4357561-4357325 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References