Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4323356..4324011 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag MR221_RS20190 Protein ID WP_003407268.1
Coordinates 4323610..4324011 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag MR221_RS20185 Protein ID WP_003407272.1
Coordinates 4323356..4323613 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS20165 4318543..4320510 - 1968 WP_003407285.1 primosomal protein N' -
MR221_RS20170 4320591..4321328 - 738 WP_031647000.1 lysoplasmalogenase -
MR221_RS20175 4321327..4322289 + 963 WP_003407279.1 alpha/beta hydrolase -
MR221_RS20180 4322314..4323273 + 960 WP_015631299.1 alpha/beta hydrolase -
MR221_RS20185 4323356..4323613 + 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
MR221_RS20190 4323610..4324011 + 402 WP_003407268.1 type II toxin-antitoxin system VapC family toxin Toxin
MR221_RS20195 4324266..4325996 + 1731 WP_031653809.1 PE family protein -
MR221_RS20200 4326042..4327076 - 1035 WP_003407264.1 AraC family transcriptional regulator -
MR221_RS20205 4327154..4328539 + 1386 WP_003407260.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T295139 WP_003407268.1 NZ_OW052188:4323610-4324011 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT295139 WP_003407272.1 NZ_OW052188:4323356-4323613 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FAR1

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References