Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4210961..4211577 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag MR221_RS19690 Protein ID WP_003407593.1
Coordinates 4210961..4211278 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag MR221_RS19695 Protein ID WP_003900349.1
Coordinates 4211275..4211577 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS19660 4205970..4206998 - 1029 Protein_3888 glycosyltransferase family 2 protein -
MR221_RS19665 4207043..4207441 - 399 WP_003900351.1 hypothetical protein -
MR221_RS19670 4207502..4207714 + 213 WP_003898900.1 dodecin family protein -
MR221_RS19675 4207835..4208545 + 711 WP_235639255.1 class I SAM-dependent methyltransferase -
MR221_RS19680 4208618..4209907 - 1290 WP_003407599.1 serine hydrolase domain-containing protein -
MR221_RS19685 4209960..4210964 - 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
MR221_RS19690 4210961..4211278 - 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
MR221_RS19695 4211275..4211577 - 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
MR221_RS19700 4211591..4213843 - 2253 WP_003407587.1 methylmalonyl-CoA mutase -
MR221_RS19705 4213844..4215691 - 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T295138 WP_003407593.1 NZ_OW052188:c4211278-4210961 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT295138 WP_003900349.1 NZ_OW052188:c4211577-4211275 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References