Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3950155..3950768 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag MR221_RS18525 Protein ID WP_003408465.1
Coordinates 3950379..3950768 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag MR221_RS18520 Protein ID WP_003408469.1
Coordinates 3950155..3950382 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS18500 3946047..3946757 + 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -
MR221_RS18505 3946747..3947166 + 420 WP_003408483.1 hypothetical protein -
MR221_RS18510 3947209..3948456 - 1248 WP_003408476.1 serine hydrolase -
MR221_RS18515 3948453..3949937 - 1485 WP_003904684.1 biotin carboxylase -
MR221_RS18520 3950155..3950382 + 228 WP_003408469.1 antitoxin Antitoxin
MR221_RS18525 3950379..3950768 + 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
MR221_RS18530 3950816..3950947 - 132 Protein_3664 IS3 family transposase -
MR221_RS18540 3951378..3952157 - 780 WP_003408460.1 IclR family transcriptional regulator -
MR221_RS18545 3952171..3952989 - 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
MR221_RS18550 3953042..3953392 - 351 WP_003898986.1 cupin domain-containing protein -
MR221_RS18555 3953392..3954222 - 831 WP_003408448.1 cyclase family protein -
MR221_RS18560 3954225..3955139 - 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T295136 WP_003408465.1 NZ_OW052188:3950379-3950768 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT295136 WP_003408469.1 NZ_OW052188:3950155-3950382 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References