295135

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3929291..3929751 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag MR221_RS18410 Protein ID WP_003898996.1
Coordinates 3929291..3929539 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JZ84
Locus tag MR221_RS18415 Protein ID WP_003904688.1
Coordinates 3929539..3929751 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS18390 3925465..3926076 + 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -
MR221_RS18395 3926066..3926467 + 402 WP_242363176.1 hypothetical protein -
MR221_RS18400 3926752..3928452 - 1701 WP_003898998.1 serine/threonine protein kinase PknE -
MR221_RS18405 3928546..3929283 - 738 WP_003898997.1 hypothetical protein -
MR221_RS18410 3929291..3929539 - 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
MR221_RS18415 3929539..3929751 - 213 WP_003904688.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR221_RS18420 3929819..3931501 + 1683 WP_242363178.1 SulP family inorganic anion transporter -
MR221_RS18425 3931515..3931799 - 285 WP_003408522.1 DUF1876 domain-containing protein -
MR221_RS18430 3932086..3933273 + 1188 WP_003898992.1 nitrate transporter NarK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T295135 WP_003898996.1 NZ_OW052188:c3929539-3929291 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7577.77 Da        Isoelectric Point: 9.3146

>AT295135 WP_003904688.1 NZ_OW052188:c3929751-3929539 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRAGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A806JZ84

References