295134

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3695625..3696328 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag MR221_RS17395 Protein ID WP_003409778.1
Coordinates 3695999..3696328 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag MR221_RS17390 Protein ID WP_003409780.1
Coordinates 3695625..3696002 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS17350 3690783..3690974 + 192 WP_003409876.1 hypothetical protein -
MR221_RS17355 3690995..3691897 + 903 WP_003409874.1 hypothetical protein -
MR221_RS17360 3691908..3692258 + 351 WP_242363164.1 hypothetical protein -
MR221_RS17365 3692372..3692554 + 183 WP_003409870.1 hypothetical protein -
MR221_RS17370 3692547..3692948 - 402 WP_003409869.1 hypothetical protein -
MR221_RS17375 3693012..3693464 + 453 WP_003899095.1 lipoprotein -
MR221_RS17380 3693619..3694983 - 1365 WP_242363165.1 HNH endonuclease signature motif containing protein -
MR221_RS17385 3695038..3695628 + 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
MR221_RS17390 3695625..3696002 + 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
MR221_RS17395 3695999..3696328 + 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MR221_RS17400 3696538..3697308 - 771 WP_003409775.1 SDR family oxidoreductase -
MR221_RS17405 3697305..3698366 - 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
MR221_RS17410 3698363..3698878 - 516 WP_003409718.1 flavin reductase family protein -
MR221_RS17415 3698875..3699945 - 1071 WP_003899091.1 epoxide hydrolase EphB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T295134 WP_003409778.1 NZ_OW052188:3695999-3696328 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT295134 WP_003409780.1 NZ_OW052188:3695625-3696002 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References