295131

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3660375..3661063 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag MR221_RS17155 Protein ID WP_003409958.1
Coordinates 3660644..3661063 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag MR221_RS17150 Protein ID WP_003409968.1
Coordinates 3660375..3660635 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS17125 3655866..3656465 - 600 WP_003409989.1 L-lysine exporter -
MR221_RS17130 3656574..3657485 + 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MR221_RS17135 3657570..3657800 - 231 WP_003409980.1 DUF167 domain-containing protein -
MR221_RS17140 3657915..3658568 + 654 WP_003409976.1 cutinase Cfp21 -
MR221_RS17145 3658556..3660232 - 1677 WP_003904753.1 PecA family PE domain-processing aspartic protease -
MR221_RS17150 3660375..3660635 + 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR221_RS17155 3660644..3661063 + 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
MR221_RS17160 3661288..3662256 + 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
MR221_RS17165 3662447..3663133 + 687 WP_003409954.1 immunoprotective protein Mpt64 -
MR221_RS17170 3663312..3664757 + 1446 WP_003409946.1 APC family permease -
MR221_RS17175 3664720..3665568 - 849 WP_003409942.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T295131 WP_003409958.1 NZ_OW052188:3660644-3661063 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT295131 WP_003409968.1 NZ_OW052188:3660375-3660635 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References