295130

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 3652836..3653734 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag MR221_RS17110 Protein ID WP_003410001.1
Coordinates 3653174..3653734 (+) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag MR221_RS17105 Protein ID WP_003410003.1
Coordinates 3652836..3653177 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS17070 3648489..3648845 + 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
MR221_RS17075 3648898..3649170 + 273 WP_003903706.1 DUF1490 family protein -
MR221_RS17080 3649167..3651482 + 2316 WP_242363161.1 cation transporter ATPase CptG -
MR221_RS17085 3651582..3651830 + 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
MR221_RS17090 3651824..3652168 + 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
MR221_RS17095 3652257..3652592 + 336 WP_003410009.1 dehydrogenase -
MR221_RS17100 3652493..3652750 - 258 WP_003410006.1 hypothetical protein -
MR221_RS17105 3652836..3653177 + 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
MR221_RS17110 3653174..3653734 + 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
MR221_RS17115 3654254..3654796 - 543 WP_242363162.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
MR221_RS17120 3655022..3655450 - 429 WP_003409992.1 cellulose-binding protein -
MR221_RS17125 3655866..3656465 - 600 WP_003409989.1 L-lysine exporter -
MR221_RS17130 3656574..3657485 + 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MR221_RS17135 3657570..3657800 - 231 WP_003409980.1 DUF167 domain-containing protein -
MR221_RS17140 3657915..3658568 + 654 WP_003409976.1 cutinase Cfp21 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T295130 WP_003410001.1 NZ_OW052188:3653174-3653734 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT295130 WP_003410003.1 NZ_OW052188:3652836-3653177 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAE4

References