Detailed information of TA system TA029513

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2696171..2696847
• Replicon: chromosome
• Accession: NC_021286
• Organism: Idiomarina loihiensis GSL 199

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q5QV92
• Locus tag: K734_RS12875
• Protein ID: WP_011235741.1
• Coordinates: 2696398..2696847 (+)
• Length: 150 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q5QV93
• Locus tag: K734_RS12870
• Protein ID: WP_011235740.1
• Coordinates: 2696171..2696401 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K734_RS12850	2691480..2692625	+	1146	WP_011235736.1	PepSY domain-containing protein	-
K734_RS12855	2692625..2693095	+	471	WP_011235737.1	hypothetical protein	-
K734_RS12860	2693168..2695309	+	2142	WP_011235738.1	TonB-dependent siderophore receptor	-
K734_RS12865	2695388..2696044	-	657	WP_011235739.1	epoxyqueuosine reductase QueH	-
K734_RS12870	2696171..2696401	+	231	WP_011235740.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
K734_RS12875	2696398..2696847	+	450	WP_011235741.1	type II toxin-antitoxin system VapC family toxin	Toxin
K734_RS12880	2696862..2697569	-	708	WP_011235742.1	ZIP family metal transporter	-
K734_RS12885	2697572..2698852	-	1281	WP_011235743.1	deoxyguanosinetriphosphate triphosphohydrolase family protein	-
K734_RS12890	2699057..2699350	+	294	WP_011235744.1	type II toxin-antitoxin system RelE/ParE family toxin	-
K734_RS12895	2699362..2699685	+	324	WP_011235745.1	HigA family addiction module antidote protein	-
K734_RS12900	2699707..2700195	-	489	WP_011235746.1	hypothetical protein	-
K734_RS12905	2700387..2701055	+	669	WP_011235747.1	hypothetical protein	-
K734_RS12910	2701052..2701450	-	399	WP_011235748.1	type II toxin-antitoxin system YafO family toxin	-
K734_RS12915	2701447..2701740	-	294	WP_011235749.1	type I toxin-antitoxin system antitoxin YafN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 150 a.a.
• Molecular weight: 17104.45 Da
• Isoelectric Point: 6.9570

>T29513 WP_011235741.1 NC_021286:2696398-2696847 [Idiomarina loihiensis GSL 199]
MNLRYMLDTNICIYIMKNRPTYLAPIFDEHSRELCISSVTVMELQYGVENSQQRTTNADKLDSFLARLKILNYDTDAAYH
TALIRHKLKQEGTPIGSYDQMIAGHARCHGLTVVTNNTKEFERVPGLITENWLQQPPQSSINEPTPAYR

Nucleotide

• Length: 450 bp

>T29513 NC_021286:2696398-2696847 [Idiomarina loihiensis GSL 199]
ATGAACTTGCGTTATATGCTCGATACGAATATCTGCATCTATATTATGAAAAATAGGCCAACATATTTAGCCCCTATTTT
TGATGAGCACTCGCGCGAGCTCTGCATCAGTTCAGTTACAGTAATGGAACTGCAATATGGTGTCGAAAACTCGCAGCAAC
GTACAACTAATGCCGACAAACTCGACAGCTTTTTGGCTCGTTTAAAAATATTAAATTACGATACTGACGCGGCTTATCAC
ACAGCACTTATTCGTCACAAACTGAAACAGGAAGGCACACCAATTGGTTCCTATGATCAGATGATAGCTGGCCATGCCCG
ATGCCATGGACTCACGGTTGTTACCAATAACACCAAAGAATTTGAACGAGTTCCCGGACTTATTACCGAAAACTGGCTGC
AACAACCACCGCAATCATCAATCAATGAGCCAACTCCGGCCTATCGTTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8647.69 Da
• Isoelectric Point: 4.3575

>AT29513 WP_011235740.1 NC_021286:2696171-2696401 [Idiomarina loihiensis GSL 199]
MTKTSLFKSNKTQAVRLPKDVAFSEDVKEVEVLVVGESRIITPAKTSWASWFTGESASDDFMIEREQPEEQERDPL

Nucleotide

• Length: 231 bp

>AT29513 NC_021286:2696171-2696401 [Idiomarina loihiensis GSL 199]
ATGACTAAAACAAGCTTATTTAAAAGTAACAAAACTCAAGCTGTCCGATTACCCAAAGACGTTGCCTTTTCCGAAGACGT
TAAAGAGGTGGAAGTTTTAGTCGTTGGTGAAAGCCGAATTATTACCCCGGCCAAAACAAGCTGGGCATCCTGGTTTACTG
GTGAATCCGCAAGTGATGACTTTATGATTGAACGCGAGCAGCCCGAGGAGCAGGAGCGTGACCCGCTATGA

Structures

Toxin

• AlphaFold DB: Q5QV92

Antitoxin

• AlphaFold DB: Q5QV93