295129

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3651582..3652168 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag MR221_RS17090 Protein ID WP_003410010.1
Coordinates 3651824..3652168 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag MR221_RS17085 Protein ID WP_003410014.1
Coordinates 3651582..3651830 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS17065 3647565..3648332 - 768 WP_003410019.1 hemerythrin domain-containing protein -
MR221_RS17070 3648489..3648845 + 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
MR221_RS17075 3648898..3649170 + 273 WP_003903706.1 DUF1490 family protein -
MR221_RS17080 3649167..3651482 + 2316 WP_242363161.1 cation transporter ATPase CptG -
MR221_RS17085 3651582..3651830 + 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
MR221_RS17090 3651824..3652168 + 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
MR221_RS17095 3652257..3652592 + 336 WP_003410009.1 dehydrogenase -
MR221_RS17100 3652493..3652750 - 258 WP_003410006.1 hypothetical protein -
MR221_RS17105 3652836..3653177 + 342 WP_003410003.1 DUF2384 domain-containing protein -
MR221_RS17110 3653174..3653734 + 561 WP_003410001.1 RES family NAD+ phosphorylase -
MR221_RS17115 3654254..3654796 - 543 WP_242363162.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
MR221_RS17120 3655022..3655450 - 429 WP_003409992.1 cellulose-binding protein -
MR221_RS17125 3655866..3656465 - 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T295129 WP_003410010.1 NZ_OW052188:3651824-3652168 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT295129 WP_003410014.1 NZ_OW052188:3651582-3651830 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAW9

References