295128

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3627802..3628428 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MR221_RS16985 Protein ID WP_057321105.1
Coordinates 3627802..3628200 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag MR221_RS16990 Protein ID WP_003911750.1
Coordinates 3628201..3628428 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS16955 3623401..3624657 + 1257 WP_003902247.1 HNH endonuclease signature motif containing protein -
MR221_RS16960 3624785..3625375 - 591 WP_003899131.1 IS110 family transposase -
MR221_RS16965 3625329..3625949 - 621 WP_003410086.1 IS110 family transposase -
MR221_RS16970 3626037..3626216 + 180 Protein_3353 hypothetical protein -
MR221_RS16975 3626653..3627087 - 435 WP_003914358.1 DUF1398 domain-containing protein -
MR221_RS16980 3627188..3627619 + 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
MR221_RS16985 3627802..3628200 - 399 WP_057321105.1 PIN domain nuclease Toxin
MR221_RS16990 3628201..3628428 - 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR221_RS16995 3628687..3629856 + 1170 WP_003899126.1 ATP-binding protein -
MR221_RS17000 3630045..3630389 + 345 WP_003410065.1 ferredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14716.99 Da        Isoelectric Point: 6.7067

>T295128 WP_057321105.1 NZ_OW052188:c3628200-3627802 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVVVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT295128 WP_003911750.1 NZ_OW052188:c3628428-3628201 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References