295126

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3560006..3560642 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MR221_RS16695 Protein ID WP_003904769.1
Coordinates 3560006..3560416 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag MR221_RS16700 Protein ID WP_003410651.1
Coordinates 3560409..3560642 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS16675 3555603..3556826 + 1224 WP_003901321.1 class I SAM-dependent methyltransferase -
MR221_RS16680 3556772..3558298 - 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
MR221_RS16685 3558295..3558921 - 627 WP_031657419.1 precorrin-8X methylmutase -
MR221_RS16690 3558931..3560022 - 1092 WP_003900454.1 precorrin-3B synthase -
MR221_RS16695 3560006..3560416 - 411 WP_003904769.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
MR221_RS16700 3560409..3560642 - 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
MR221_RS16705 3560720..3564304 + 3585 WP_003410648.1 cobaltochelatase subunit CobN -
MR221_RS16710 3564388..3564792 + 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
MR221_RS16715 3564793..3565194 - 402 WP_009937711.1 metal ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14176.35 Da        Isoelectric Point: 9.4835

>T295126 WP_003904769.1 NZ_OW052188:c3560416-3560006 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMPAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT295126 WP_003410651.1 NZ_OW052188:c3560642-3560409 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BV50

References