Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3075284..3075936 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag MR221_RS14395 Protein ID WP_003412752.1
Coordinates 3075284..3075709 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag MR221_RS14400 Protein ID WP_003412749.1
Coordinates 3075715..3075936 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS14370 3070289..3070846 + 558 WP_003412768.1 MaoC family dehydratase -
MR221_RS14375 3070843..3071664 + 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
MR221_RS14380 3071923..3073026 + 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
MR221_RS14385 3073037..3074083 + 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
MR221_RS14390 3074080..3075261 + 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
MR221_RS14395 3075284..3075709 - 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
MR221_RS14400 3075715..3075936 - 222 WP_003412749.1 antitoxin Antitoxin
MR221_RS14405 3075989..3076741 - 753 WP_003901416.1 hypothetical protein -
MR221_RS14410 3076731..3077354 - 624 WP_003900858.1 TIGR00725 family protein -
MR221_RS14415 3077490..3077696 + 207 WP_003899347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T295123 WP_003412752.1 NZ_OW052188:c3075709-3075284 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT295123 WP_003412749.1 NZ_OW052188:c3075936-3075715 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References