295116

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2823009..2823696 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TF65
Locus tag MR221_RS13055 Protein ID WP_003414064.1
Coordinates 2823009..2823404 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag MR221_RS13060 Protein ID WP_003414061.1
Coordinates 2823430..2823696 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS13020 2818906..2819643 - 738 WP_003414079.1 dienelactone hydrolase family protein -
MR221_RS13025 2819799..2820599 + 801 WP_003911953.1 thymidylate synthase -
MR221_RS13030 2820670..2821149 + 480 WP_003414073.1 dihydrofolate reductase -
MR221_RS13035 2821150..2821224 - 75 Protein_2578 hypothetical protein -
MR221_RS13040 2821223..2821642 + 420 WP_003414070.1 winged helix-turn-helix domain-containing protein -
MR221_RS13045 2821639..2822733 + 1095 WP_003414068.1 restriction endonuclease subunit S -
MR221_RS13050 2822743..2823012 + 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
MR221_RS13055 2823009..2823404 + 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin Toxin
MR221_RS13060 2823430..2823696 + 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR221_RS13065 2823693..2824109 + 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 -
MR221_RS13070 2824196..2825818 + 1623 WP_242363130.1 class I SAM-dependent DNA methyltransferase -
MR221_RS13075 2825815..2826090 + 276 WP_003414055.1 type I restriction endonuclease subunit S -
MR221_RS13085 2826334..2827086 + 753 WP_031657460.1 FAD-dependent thymidylate synthase -
MR221_RS13090 2827155..2828057 + 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14340.04 Da        Isoelectric Point: 4.7145

>T295116 WP_003414064.1 NZ_OW052188:2823009-2823404 [Mycobacterium tuberculosis]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT

Download         Length: 396 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT295116 WP_003414061.1 NZ_OW052188:2823430-2823696 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TF65

Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References