Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2783540..2784110 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag MR221_RS12835 Protein ID WP_003414166.1
Coordinates 2783754..2784110 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag MR221_RS12830 Protein ID WP_003901465.1
Coordinates 2783540..2783770 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS12790 2778558..2778869 - 312 WP_003414190.1 hypothetical protein -
MR221_RS12795 2778974..2779231 - 258 WP_003899489.1 hypothetical protein -
MR221_RS12800 2780341..2780601 - 261 Protein_2531 transposase -
MR221_RS12805 2780818..2781009 - 192 WP_003414184.1 hypothetical protein -
MR221_RS12810 2781006..2781410 - 405 WP_003414181.1 hypothetical protein -
MR221_RS12815 2781558..2781812 + 255 WP_003917684.1 hypothetical protein -
MR221_RS12820 2781988..2782455 - 468 WP_003414177.1 DUF1778 domain-containing protein -
MR221_RS12825 2782454..2783497 + 1044 WP_003414172.1 DUF2293 domain-containing protein -
MR221_RS12830 2783540..2783770 + 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
MR221_RS12835 2783754..2784110 + 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
MR221_RS12840 2784212..2785861 - 1650 WP_003899485.1 CocE/NonD family hydrolase -
MR221_RS12845 2785880..2786467 - 588 WP_003914429.1 DUF3558 family protein -
MR221_RS12850 2786640..2786966 + 327 WP_003414157.1 hypothetical protein -
MR221_RS12855 2786970..2788658 + 1689 WP_003414155.1 alpha/beta hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T295115 WP_003414166.1 NZ_OW052188:2783754-2784110 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT295115 WP_003901465.1 NZ_OW052188:2783540-2783770 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References