Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 2757430..2759204 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name abiEi Uniprot ID P71626
Locus tag MR221_RS12710 Protein ID WP_003414409.1
Coordinates 2758320..2759204 (+) Length 295 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID P71625
Locus tag MR221_RS12705 Protein ID WP_003414414.1
Coordinates 2757430..2758317 (+) Length 296 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS12675 2753732..2754814 + 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
MR221_RS12680 2754893..2755642 - 750 WP_003414497.1 enoyl-CoA hydratase -
MR221_RS12685 2755689..2755904 + 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR221_RS12690 2755901..2756293 + 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin -
MR221_RS12695 2756314..2756583 + 270 WP_003414489.1 DUF2277 family protein -
MR221_RS12700 2756580..2757125 + 546 WP_003908074.1 DUF1802 family protein -
MR221_RS12705 2757430..2758317 + 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
MR221_RS12710 2758320..2759204 + 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MR221_RS12715 2759476..2760021 + 546 WP_003904931.1 DUF1802 family protein -
MR221_RS12720 2760355..2761143 + 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
MR221_RS12725 2761140..2763578 + 2439 WP_003900580.1 type III-A CRISPR-associated protein Cas10/Csm1 -
MR221_RS12730 2763575..2763949 + 375 WP_003414296.1 type III-A CRISPR-associated protein Csm2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-272)

Antitoxin

AbiEi antitoxin C-terminal domain

(84-237)


Sequences

Toxin        


Download         Length: 295 a.a.        Molecular weight: 33056.72 Da        Isoelectric Point: 7.1520

>T295114 WP_003414409.1 NZ_OW052188:2758320-2759204 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS

Download         Length: 885 bp

Antitoxin


Download         Length: 296 a.a.        Molecular weight: 32315.19 Da        Isoelectric Point: 9.4723

>AT295114 WP_003414414.1 NZ_OW052188:2757430-2758317 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA

Download         Length: 888 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6Y56

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBU9

References