295112

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2714828..2715376 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag MR221_RS12495 Protein ID WP_003414602.1
Coordinates 2714828..2715091 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag MR221_RS12500 Protein ID WP_003414599.1
Coordinates 2715095..2715376 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS12475 2709902..2711143 + 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
MR221_RS12480 2711151..2712365 + 1215 WP_003414610.1 zinc metalloprotease Rip -
MR221_RS12485 2712382..2713545 + 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MR221_RS12490 2713601..2714455 + 855 WP_003899516.1 GNAT family N-acetyltransferase -
MR221_RS12495 2714828..2715091 - 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MR221_RS12500 2715095..2715376 - 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
MR221_RS12505 2715648..2717459 + 1812 WP_003414596.1 penicillin-binding protein -
MR221_RS12510 2717541..2717921 - 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
MR221_RS12515 2717918..2718166 - 249 WP_003913411.1 antitoxin VapB23 -
MR221_RS12520 2718270..2718854 + 585 WP_003414585.1 DUF1707 domain-containing protein -
MR221_RS12525 2718896..2719753 + 858 WP_003899513.1 type I methionyl aminopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T295112 WP_003414602.1 NZ_OW052188:c2715091-2714828 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT295112 WP_003414599.1 NZ_OW052188:c2715376-2715095 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWP8

References