295111

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2709088..2709775 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag MR221_RS12465 Protein ID WP_003414624.1
Coordinates 2709088..2709531 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag MR221_RS12470 Protein ID WP_003414620.1
Coordinates 2709518..2709775 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS12440 2704936..2705202 - 267 WP_015456449.1 DUF2631 domain-containing protein -
MR221_RS12445 2705302..2705883 - 582 WP_003414644.1 fasciclin domain-containing protein -
MR221_RS12450 2705979..2707727 - 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
MR221_RS12455 2708059..2708250 - 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
MR221_RS12460 2708346..2709008 - 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
MR221_RS12465 2709088..2709531 - 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
MR221_RS12470 2709518..2709775 - 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
MR221_RS12475 2709902..2711143 + 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
MR221_RS12480 2711151..2712365 + 1215 WP_003414610.1 zinc metalloprotease Rip -
MR221_RS12485 2712382..2713545 + 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MR221_RS12490 2713601..2714455 + 855 WP_003899516.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T295111 WP_003414624.1 NZ_OW052188:c2709531-2709088 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT295111 WP_003414620.1 NZ_OW052188:c2709775-2709518 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
AlphaFold DB G0TFH0

References