Detailed information of TA system TA029511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1386743..1387296
• Replicon: chromosome
• Accession: NC_021286
• Organism: Idiomarina loihiensis GSL 199

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q5QYX8
• Locus tag: K734_RS06605
• Protein ID: WP_011234535.1
• Coordinates: 1386743..1387036 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q5QYX7
• Locus tag: K734_RS06610
• Protein ID: WP_011234536.1
• Coordinates: 1387024..1387296 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K734_RS06590	1383589..1383765	+	177	WP_011234532.1	ribosome modulation factor	-
K734_RS06595	1383839..1384351	-	513	WP_011234533.1	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA	-
K734_RS06600	1384434..1386350	-	1917	WP_011234534.1	Lon protease family protein	-
K734_RS06605	1386743..1387036	-	294	WP_011234535.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K734_RS06610	1387024..1387296	-	273	WP_011234536.1	CopG family ribbon-helix-helix protein	Antitoxin
K734_RS06615	1387795..1388706	-	912	WP_011234537.1	LysR family transcriptional regulator	-
K734_RS06620	1388821..1389381	+	561	WP_011234538.1	NAD(P)H-dependent oxidoreductase	-
K734_RS06625	1389399..1389590	-	192	WP_011234539.1	CPXCG motif-containing cysteine-rich protein	-
K734_RS06630	1389693..1390772	+	1080	WP_011234540.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11110.82 Da
• Isoelectric Point: 7.2006

>T29511 WP_011234535.1 NC_021286:c1387036-1386743 [Idiomarina loihiensis GSL 199]
VSQVIWSPAALADVKRLHDFLRDKDPIVARKAVKSIRQNVLILAGQPEIGRPLDDMPIEFREWLIDFGQSGYVALYRYDG
FETIILAVRHQKEVGYS

Nucleotide

• Length: 294 bp

>T29511 NC_021286:c1387036-1386743 [Idiomarina loihiensis GSL 199]
GTGTCACAAGTAATTTGGTCCCCGGCCGCTTTAGCGGACGTGAAACGTCTGCATGATTTTTTACGAGATAAAGACCCGAT
AGTGGCCCGTAAGGCCGTCAAAAGCATTCGCCAAAACGTCCTTATTTTGGCTGGCCAACCCGAGATTGGCCGCCCGCTGG
ATGATATGCCCATTGAATTTAGAGAGTGGCTCATTGATTTTGGCCAGAGCGGTTATGTTGCTCTCTACCGTTACGATGGC
TTTGAAACGATCATCCTTGCGGTGCGACACCAAAAGGAAGTTGGCTATTCGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10633.83 Da
• Isoelectric Point: 5.9830

>AT29511 WP_011234536.1 NC_021286:c1387296-1387024 [Idiomarina loihiensis GSL 199]
MATSVKLNDDMKKRVQNLANVRHRSSHWIMRQAIQDYVEREEKREAFKQDALRAWEDYQHNGLHLTAEEADEWLAKLESG
DDAELPTCHK

Nucleotide

• Length: 273 bp

>AT29511 NC_021286:c1387296-1387024 [Idiomarina loihiensis GSL 199]
ATGGCAACATCCGTAAAACTGAATGACGACATGAAAAAACGCGTGCAAAATCTGGCGAACGTCCGGCACCGTTCCTCACA
CTGGATCATGCGTCAGGCGATCCAGGATTATGTTGAACGTGAAGAAAAACGGGAAGCGTTTAAACAGGACGCACTTCGCG
CCTGGGAGGATTATCAGCATAATGGTTTGCATTTGACGGCAGAGGAAGCTGATGAATGGTTAGCCAAACTTGAATCGGGT
GACGATGCTGAGCTGCCGACGTGTCACAAGTAA

Structures

Toxin

• AlphaFold DB: Q5QYX8

Antitoxin

• AlphaFold DB: Q5QYX7