295108

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 2117726..2118255 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag MR221_RS09890 Protein ID WP_003417760.1
Coordinates 2117726..2117983 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag MR221_RS09895 Protein ID WP_003417757.1
Coordinates 2117980..2118255 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS09860 2114154..2114546 + 393 WP_003417776.1 serine protease inhibitor -
MR221_RS09865 2114524..2114892 + 369 WP_003417772.1 DUF742 domain-containing protein -
MR221_RS09870 2114873..2115454 + 582 WP_003417769.1 ATP/GTP-binding protein -
MR221_RS09875 2115461..2116012 + 552 WP_003417767.1 pentapeptide repeat protein MfpA -
MR221_RS09880 2116009..2116377 - 369 WP_242363297.1 FHA domain-containing protein -
MR221_RS09885 2116494..2117684 - 1191 WP_003900033.1 NADH:flavin oxidoreductase -
MR221_RS09890 2117726..2117983 - 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
MR221_RS09895 2117980..2118255 - 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
MR221_RS09900 2118379..2119224 + 846 WP_003905054.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
MR221_RS09905 2119221..2119514 + 294 WP_003417749.1 DUF3017 domain-containing protein -
MR221_RS09910 2119528..2119917 - 390 WP_003417745.1 DUF732 domain-containing protein -
MR221_RS09915 2120032..2120292 + 261 WP_003417741.1 hypothetical protein -
MR221_RS09920 2120319..2120806 + 488 Protein_1959 FAD-binding protein -
MR221_RS09925 2120993..2121682 + 690 WP_003917774.1 BBE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T295108 WP_003417760.1 NZ_OW052188:c2117983-2117726 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT295108 WP_003417757.1 NZ_OW052188:c2118255-2117980 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References