295107

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 2090465..2091132 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag MR221_RS09770 Protein ID WP_003417916.1
Coordinates 2090740..2091132 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag MR221_RS09765 Protein ID WP_003912214.1
Coordinates 2090465..2090740 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS09750 2085509..2086381 + 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -
MR221_RS09755 2086452..2088722 - 2271 WP_031653948.1 PE family protein -
MR221_RS09760 2088912..2090283 - 1372 Protein_1927 ISNCY family transposase -
MR221_RS09765 2090465..2090740 + 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MR221_RS09770 2090740..2091132 + 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
MR221_RS09775 2091886..2092938 + 1053 WP_003900678.1 polyprenyl synthetase family protein -
MR221_RS09780 2092938..2093927 + 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MR221_RS09785 2093924..2095762 + 1839 WP_019830554.1 1-deoxy-D-xylulose-5-phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2088912..2089589 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T295107 WP_003417916.1 NZ_OW052188:2090740-2091132 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT295107 WP_003912214.1 NZ_OW052188:2090465-2090740 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References