295102

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1112300..1112943 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag MR221_RS05355 Protein ID WP_003401566.1
Coordinates 1112300..1112725 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag MR221_RS05360 Protein ID WP_003401563.1
Coordinates 1112722..1112943 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS05345 1110627..1111535 - 909 WP_242363249.1 SDR family NAD(P)-dependent oxidoreductase -
MR221_RS05350 1111532..1112164 - 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
MR221_RS05355 1112300..1112725 - 426 WP_003401566.1 PIN domain nuclease Toxin
MR221_RS05360 1112722..1112943 - 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
MR221_RS05365 1112991..1113293 - 303 WP_003401560.1 toxin-antitoxin system toxin -
MR221_RS05370 1113290..1113517 - 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
MR221_RS05375 1113660..1115480 - 1821 WP_031653699.1 PE family protein -
MR221_RS05380 1115659..1117056 + 1398 WP_003401544.1 sulfatase -
MR221_RS05385 1117066..1117869 + 804 WP_003401540.1 Stf0 family sulphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T295102 WP_003401566.1 NZ_OW052188:c1112725-1112300 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT295102 WP_003401563.1 NZ_OW052188:c1112943-1112722 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
AlphaFold DB A0A829CG48

References