Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 1031625..1032636 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag MR221_RS05035 Protein ID WP_003401859.1
Coordinates 1032043..1032636 (+) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag MR221_RS05030 Protein ID WP_003401860.1
Coordinates 1031625..1032014 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS05005 1027473..1028228 + 756 WP_003401865.1 XdhC family protein -
MR221_RS05010 1028225..1028818 + 594 WP_003401864.1 NTP transferase domain-containing protein -
MR221_RS05015 1028815..1029711 + 897 WP_003902972.1 MoxR family ATPase -
MR221_RS05020 1029725..1030327 + 603 WP_242363247.1 SRPBCC family protein -
MR221_RS05025 1030333..1031544 + 1212 WP_003904390.1 VWA domain-containing protein -
MR221_RS05030 1031625..1032014 + 390 WP_003401860.1 hypothetical protein Antitoxin
MR221_RS05035 1032043..1032636 + 594 WP_003401859.1 zeta toxin family protein Toxin
MR221_RS05040 1032661..1033791 + 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
MR221_RS05045 1033780..1034463 - 684 WP_003401857.1 VTT domain-containing protein -
MR221_RS05050 1034559..1035593 + 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
MR221_RS05055 1035605..1036987 - 1383 WP_003898415.1 magnesium transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T295101 WP_003401859.1 NZ_OW052188:1032043-1032636 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT295101 WP_003401860.1 NZ_OW052188:1031625-1032014 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References