Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 835352..836028 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag MR221_RS04080 Protein ID WP_003898500.1
Coordinates 835615..836028 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag MR221_RS04075 Protein ID WP_003402915.1
Coordinates 835352..835618 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS04060 830786..831766 - 981 WP_003402923.1 o-succinylbenzoate synthase -
MR221_RS04065 831763..833367 - 1605 WP_242363230.1 amidohydrolase -
MR221_RS04070 833445..835160 + 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
MR221_RS04075 835352..835618 + 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MR221_RS04080 835615..836028 + 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
MR221_RS04085 836342..837244 + 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
MR221_RS04090 837340..838224 + 885 WP_003402909.1 SDR family oxidoreductase -
MR221_RS04095 838287..838673 + 387 WP_003402907.1 VOC family protein -
MR221_RS04100 838793..840046 + 1254 WP_242363231.1 inorganic phosphate transporter -
MR221_RS04105 840043..840321 + 279 WP_003402901.1 hypothetical protein -
MR221_RS04110 840381..840683 + 303 WP_003402896.1 DUF3349 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T295100 WP_003898500.1 NZ_OW052188:835615-836028 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT295100 WP_003402915.1 NZ_OW052188:835352-835618 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References