295096

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 772341..772984 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag MR221_RS03775 Protein ID WP_003403187.1
Coordinates 772341..772742 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag MR221_RS03780 Protein ID WP_003403184.1
Coordinates 772739..772984 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS03750 769299..769904 - 606 WP_003898526.1 hypothetical protein -
MR221_RS03755 770046..770267 + 222 WP_003898525.1 DUF4926 domain-containing protein -
MR221_RS03760 770319..771476 + 1158 Protein_738 hypothetical protein -
MR221_RS03765 771556..771753 + 198 WP_003403191.1 hypothetical protein -
MR221_RS03770 772171..772350 - 180 Protein_740 hypothetical protein -
MR221_RS03775 772341..772742 - 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
MR221_RS03780 772739..772984 - 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR221_RS03785 773029..773499 - 471 WP_003898523.1 hypothetical protein -
MR221_RS03790 773502..774212 - 711 Protein_744 IS607 family element RNA-guided endonuclease TnpB -
MR221_RS03795 774214..774798 - 585 WP_003403171.1 IS607-like element IS1536 family transposase -
MR221_RS03800 775039..775989 - 951 WP_003907436.1 DUF1259 domain-containing protein -
MR221_RS03805 776061..776372 - 312 WP_003403164.1 hypothetical protein -
MR221_RS03810 776495..777190 + 696 WP_200861092.1 two-component system response regulator TcrA -
MR221_RS03815 777174..777704 + 531 WP_003917320.1 two component system sensor kinase HK2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T295096 WP_003403187.1 NZ_OW052188:c772742-772341 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT295096 WP_003403184.1 NZ_OW052188:c772984-772739 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References