295095

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 764821..765446 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MR221_RS03725 Protein ID WP_003403218.1
Coordinates 764821..765222 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MR221_RS03730 Protein ID WP_003403213.1
Coordinates 765219..765446 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS03700 759910..760857 - 948 WP_003403232.1 DUF732 domain-containing protein -
MR221_RS03705 760868..762025 - 1158 WP_003903091.1 hypothetical protein -
MR221_RS03710 762420..763511 - 1092 WP_242363226.1 galactokinase -
MR221_RS03715 763508..764590 - 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
MR221_RS03720 764609..764692 - 84 Protein_730 galactose-1-phosphate uridylyltransferase -
MR221_RS03725 764821..765222 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MR221_RS03730 765219..765446 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MR221_RS03735 765641..765883 - 243 WP_003403210.1 hypothetical protein -
MR221_RS03740 765880..766629 - 750 WP_003898528.1 hypothetical protein -
MR221_RS03745 766713..769280 + 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
MR221_RS03750 769299..769904 - 606 WP_003898526.1 hypothetical protein -
MR221_RS03755 770046..770267 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T295095 WP_003403218.1 NZ_OW052188:c765222-764821 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT295095 WP_003403213.1 NZ_OW052188:c765446-765219 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References