295094

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 759168..759817 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag MR221_RS03690 Protein ID WP_003403236.1
Coordinates 759168..759563 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag MR221_RS03695 Protein ID WP_003403235.1
Coordinates 759563..759817 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS03665 754495..756222 + 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -
MR221_RS03670 756315..757466 + 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
MR221_RS03675 757538..757945 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
MR221_RS03680 757942..758202 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR221_RS03685 758334..759074 + 741 WP_242363225.1 TVP38/TMEM64 family protein -
MR221_RS03690 759168..759563 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
MR221_RS03695 759563..759817 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
MR221_RS03700 759910..760857 - 948 WP_003403232.1 DUF732 domain-containing protein -
MR221_RS03705 760868..762025 - 1158 WP_003903091.1 hypothetical protein -
MR221_RS03710 762420..763511 - 1092 WP_242363226.1 galactokinase -
MR221_RS03715 763508..764590 - 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
MR221_RS03720 764609..764692 - 84 Protein_730 galactose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T295094 WP_003403236.1 NZ_OW052188:c759563-759168 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT295094 WP_003403235.1 NZ_OW052188:c759817-759563 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC2

References