295093

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 757538..758202 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P96917
Locus tag MR221_RS03675 Protein ID WP_003403246.1
Coordinates 757538..757945 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF18
Locus tag MR221_RS03680 Protein ID WP_003403244.1
Coordinates 757942..758202 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS03665 754495..756222 + 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -
MR221_RS03670 756315..757466 + 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
MR221_RS03675 757538..757945 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin Toxin
MR221_RS03680 757942..758202 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MR221_RS03685 758334..759074 + 741 WP_242363225.1 TVP38/TMEM64 family protein -
MR221_RS03690 759168..759563 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 -
MR221_RS03695 759563..759817 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 -
MR221_RS03700 759910..760857 - 948 WP_003403232.1 DUF732 domain-containing protein -
MR221_RS03705 760868..762025 - 1158 WP_003903091.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14376.37 Da        Isoelectric Point: 4.3568

>T295093 WP_003403246.1 NZ_OW052188:c757945-757538 [Mycobacterium tuberculosis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Download         Length: 408 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9492.84 Da        Isoelectric Point: 11.9108

>AT295093 WP_003403244.1 NZ_OW052188:c758202-757942 [Mycobacterium tuberculosis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3DBO

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSE4

References