295090

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 719922..720714 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag MR221_RS03480 Protein ID WP_003403386.1
Coordinates 719922..720359 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag MR221_RS03485 Protein ID WP_003403381.1
Coordinates 720469..720714 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS03455 716385..716558 - 174 WP_003898549.1 hypothetical protein -
MR221_RS03460 716555..716893 - 339 WP_003403405.1 PIN domain-containing protein -
MR221_RS03465 716805..717131 - 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR221_RS03470 717194..719557 - 2364 WP_003403397.1 arylsulfatase AtsD -
MR221_RS03475 719671..719925 + 255 WP_003911263.1 antitoxin VapB7 -
MR221_RS03480 719922..720359 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
MR221_RS03485 720469..720714 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
MR221_RS03490 720701..721009 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
MR221_RS03495 721285..722001 + 717 WP_003903122.1 CPBP family intramembrane metalloprotease -
MR221_RS03500 722077..722232 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
MR221_RS03505 722327..722710 + 384 WP_003403365.1 ribonuclease VapC6 -
MR221_RS03510 723098..724108 - 1011 WP_031653722.1 ABC transporter ATP-binding protein -
MR221_RS03515 724189..725694 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T295090 WP_003403386.1 NZ_OW052188:719922-720359 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT295090 WP_003403381.1 NZ_OW052188:720469-720714 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References