Detailed information of TA system TA029509

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 300927..301437
• Replicon: chromosome
• Accession: NC_021286
• Organism: Idiomarina loihiensis GSL 199

Toxin (Protein)

• Gene name: relB
• Uniprot ID: Q5R151
• Locus tag: K734_RS01430
• Protein ID: WP_011233548.1
• Coordinates: 301174..301437 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q5QUM2
• Locus tag: K734_RS01425
• Protein ID: WP_011233547.1
• Coordinates: 300927..301181 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K734_RS01410	297989..298468	-	480	WP_011233544.1	transcription elongation factor GreB	-
K734_RS01415	298650..298865	+	216	WP_011233545.1	TIGR02450 family Trp-rich protein	-
K734_RS01420	299024..300652	-	1629	WP_011233546.1	hypothetical protein	-
K734_RS01425	300927..301181	+	255	WP_011233547.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
K734_RS01430	301174..301437	+	264	WP_011233548.1	Txe/YoeB family addiction module toxin	Toxin
K734_RS01435	301633..302124	+	492	WP_011233549.1	hypothetical protein	-
K734_RS01440	302235..302789	+	555	WP_011233550.1	hypothetical protein	-
K734_RS01445	302845..303225	+	381	WP_011233551.1	hypothetical protein	-
K734_RS01450	303276..303830	+	555	WP_011233552.1	YaeQ family protein	-
K734_RS01455	303914..304738	-	825	WP_011233553.1	hypothetical protein	-
K734_RS01460	304856..305968	+	1113	WP_011233554.1	DUF4241 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10353.81 Da
• Isoelectric Point: 9.7108

>T29509 WP_011233548.1 NC_021286:301174-301437 [Idiomarina loihiensis GSL 199]
MSKRLLSWTDEAWKDYLYWQTQDKKTLKRINRLVADVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAADDSAITI
ISCRYHY

Nucleotide

• Length: 264 bp

>T29509 NC_021286:301174-301437 [Idiomarina loihiensis GSL 199]
ATGAGTAAGAGGTTGCTGTCATGGACTGATGAGGCCTGGAAAGACTATTTATATTGGCAGACTCAAGATAAAAAGACACT
TAAACGTATCAACAGATTAGTTGCCGATGTTAAAAGATCGCCGTTCGAAGGTATTGGTAAACCTGAGCCGTTAAAAGAAA
ACCTGGCGGGTTTCTGGTCGCGGCGAATCGATGATACGAATAGACTGGTATACGCAGCCGACGACAGTGCAATTACAATT
ATTTCTTGTCGTTATCACTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9496.75 Da
• Isoelectric Point: 5.6993

>AT29509 WP_011233547.1 NC_021286:300927-301181 [Idiomarina loihiensis GSL 199]
MRIVSFTEARNGLKAVLDSVINDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNKSIAQYKEGKAKKRE
LLDE

Nucleotide

• Length: 255 bp

>AT29509 NC_021286:300927-301181 [Idiomarina loihiensis GSL 199]
ATGAGAATAGTCTCTTTTACTGAAGCCCGAAATGGCTTAAAAGCAGTGTTGGACAGCGTAATCAACGATGCTGATACAAC
GGTTATTACCCGTCGTGACTCGGAAGATGCCGTGGTTATGTCTTTAGATTACTACAATAGCCTAATGGAAACGGTTCATT
TGCTCCGTTCGCCGGCAAATGCTGAGCATTTGAATAAATCTATTGCTCAATACAAAGAAGGGAAAGCCAAAAAGAGAGAG
TTATTAGATGAGTAA

Structures

Toxin

• AlphaFold DB: Q5R151

Antitoxin

• AlphaFold DB: Q5QUM2