295087

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 461190..461809 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MR221_RS02165 Protein ID WP_003404726.1
Coordinates 461190..461624 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID G0TFQ5
Locus tag MR221_RS02170 Protein ID WP_003404724.1
Coordinates 461630..461809 (-) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS02140 456525..457763 + 1239 WP_003404744.1 acetyl-CoA acetyltransferase -
MR221_RS02145 457765..459273 + 1509 WP_003404742.1 carotenoid oxygenase family protein -
MR221_RS02150 459440..459670 + 231 WP_003898642.1 hypothetical protein -
MR221_RS02155 459805..460254 - 450 WP_003404738.1 hypothetical protein -
MR221_RS02160 460319..461092 - 774 WP_003404735.1 VOC family protein -
MR221_RS02165 461190..461624 - 435 WP_003404726.1 SRPBCC family protein Toxin
MR221_RS02170 461630..461809 - 180 WP_003404724.1 antitoxin Antitoxin
MR221_RS02175 461935..462093 - 159 WP_003404720.1 hypothetical protein -
MR221_RS02180 462366..464759 - 2394 WP_003898639.1 cation-translocating P-type ATPase -
MR221_RS02185 464756..466336 - 1581 WP_003909313.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T295087 WP_003404726.1 NZ_OW052188:c461624-461190 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6394.06 Da        Isoelectric Point: 4.3059

>AT295087 WP_003404724.1 NZ_OW052188:c461809-461630 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TFQ5

References