295084

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 246755..247386 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag MR221_RS01115 Protein ID WP_003405820.1
Coordinates 247075..247386 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag MR221_RS01110 Protein ID WP_003405836.1
Coordinates 246755..247075 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS01085 241951..242589 + 639 WP_003898730.1 lipid droplet-associated protein -
MR221_RS01090 242586..243833 + 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
MR221_RS01095 243823..244080 + 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
MR221_RS01100 244090..245202 + 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
MR221_RS01105 245209..246745 - 1537 Protein_219 carboxylesterase/lipase family protein -
MR221_RS01110 246755..247075 + 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
MR221_RS01115 247075..247386 + 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
MR221_RS01120 247498..248655 + 1158 WP_003898727.1 AI-2E family transporter -
MR221_RS01125 248662..249306 - 645 WP_003915494.1 DUF4245 domain-containing protein -
MR221_RS01130 249362..250453 + 1092 WP_242363202.1 class II fructose-bisphosphatase -
MR221_RS01135 250484..251908 + 1425 WP_003405805.1 class II fumarate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T295084 WP_003405820.1 NZ_OW052188:247075-247386 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT295084 WP_003405836.1 NZ_OW052188:246755-247075 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References