Detailed information of TA system TA295080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4438661..4439264
• Replicon: chromosome
• Accession: NZ_OW011623
• Organism: Thauera sp. PIV-1 strain Piv1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: QM552_RS20690
• Protein ID: WP_282811044.1
• Coordinates: 4438899..4439264 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: QM552_RS20685
• Protein ID: WP_282811045.1
• Coordinates: 4438661..4438912 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QM552_RS20660 (C4PIVTH_4337)	4433884..4434672	+	789	WP_282811573.1	helix-turn-helix transcriptional regulator	-
QM552_RS20665 (C4PIVTH_4338)	4434857..4435768	+	912	WP_282811574.1	nucleoside diphosphate kinase regulator	-
QM552_RS20670 (C4PIVTH_4339)	4436027..4436443	-	417	WP_282811575.1	hypothetical protein	-
QM552_RS20675 (C4PIVTH_4340)	4436488..4437810	-	1323	WP_282809941.1	ISL3 family transposase	-
QM552_RS20680 (C4PIVTH_4341)	4437828..4438361	-	534	WP_282811576.1	hypothetical protein	-
QM552_RS20685 (C4PIVTH_4342)	4438661..4438912	+	252	WP_282811045.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
QM552_RS20690 (C4PIVTH_4343)	4438899..4439264	+	366	WP_282811044.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QM552_RS20695 (C4PIVTH_4344)	4439298..4440266	-	969	WP_282811043.1	IS1595 family transposase	-
QM552_RS20700 (C4PIVTH_4345)	4440337..4441380	+	1044	WP_282811577.1	DMT family transporter	-
QM552_RS20705 (C4PIVTH_4346)	4441757..4442137	+	381	WP_282811578.1	CIA30 family protein	-
QM552_RS20710 (C4PIVTH_4347)	4442244..4442966	-	723	WP_282811579.1	ABC transporter ATP-binding protein	-
QM552_RS20715 (C4PIVTH_4348)	4442968..4444173	-	1206	WP_282811580.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4429638..4496980	67342

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (17-92)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-76)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13961.35 Da
• Isoelectric Point: 10.3533

>T295080 WP_282811044.1 NZ_OW011623:4438899-4439264 [Thauera sp. PIV-1]
MTKSEPSRKYKYRLFFIPSALQEWRDLDGSVKEPLRKLLRKRLNNPHVPGGALHGELEGYYKIKLRKQGYRLVYGVEDDA
LIVMVMAVDKREDGAVYRSVLARLAEKATELAKAVKERLIT

Nucleotide

• Length: 366 bp

>T295080 NZ_OW011623:4438899-4439264 [Thauera sp. PIV-1]
TTGACGAAATCTGAGCCGTCGAGGAAATACAAGTACCGGCTCTTCTTCATCCCCTCTGCGTTGCAGGAGTGGCGTGACCT
CGACGGTTCGGTGAAGGAGCCGTTGCGCAAGCTCCTGCGCAAGCGGTTGAACAACCCGCATGTCCCCGGCGGTGCGCTCC
ACGGGGAGCTTGAGGGCTACTACAAGATCAAGCTCAGGAAGCAGGGGTATCGGCTGGTCTACGGCGTGGAGGACGACGCG
CTCATCGTAATGGTCATGGCAGTCGACAAGCGAGAGGACGGAGCGGTCTATCGCTCGGTTCTCGCGCGGCTCGCCGAAAA
GGCCACCGAGCTGGCGAAGGCCGTCAAGGAAAGGCTCATCACGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9486.90 Da
• Isoelectric Point: 4.4488

>AT295080 WP_282811045.1 NZ_OW011623:4438661-4438912 [Thauera sp. PIV-1]
MQTILTDITVSMSEFKKNPAYVLREANSRPVAVLNHNKAAFYMVEPKLFQAMVEELADQDLYRTVLARVAEKEQAVEVDI
DEI

Nucleotide

• Length: 252 bp

>AT295080 NZ_OW011623:4438661-4438912 [Thauera sp. PIV-1]
ATGCAAACGATTCTCACGGACATCACGGTCAGCATGTCGGAGTTCAAGAAGAACCCCGCTTACGTGCTGCGCGAAGCGAA
CAGCCGCCCGGTGGCGGTCCTCAACCACAACAAGGCCGCCTTCTACATGGTGGAGCCGAAGCTGTTTCAGGCGATGGTAG
AGGAGCTGGCCGACCAAGACCTGTATCGCACGGTGTTGGCTCGGGTTGCCGAGAAGGAGCAAGCCGTCGAGGTCGACATT
GACGAAATCTGA