Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 60107..61692 Replicon chromosome
Accession NC_021286
Organism Idiomarina loihiensis GSL 199

Toxin (Protein)


Gene name hipA Uniprot ID Q5QZX8
Locus tag K734_RS00290 Protein ID WP_011233322.1
Coordinates 60379..61692 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K734_RS00285 Protein ID WP_011233321.1
Coordinates 60107..60379 (+) Length 91 a.a.

Genomic Context

K734_RS00260K734_RS00265K734_RS00270K734_RS00280K734_RS00285K734_RS00290K734_RS00300K734_RS00305K734_RS00275K734_RS00295
Location: 55329..56225 (897 bp)
Type: Others
Protein ID: WP_011233317.1
Location: 57043..57585 (543 bp)
Type: Others
Protein ID: WP_011233318.1
Location: 57575..58429 (855 bp)
Type: Others
Protein ID: WP_011233319.1
Location: 59394..59717 (324 bp)
Type: Others
Protein ID: WP_081423212.1
Location: 60107..60379 (273 bp)
Type: Antitoxin
Protein ID: WP_011233321.1
Location: 60379..61692 (1314 bp)
Type: Toxin
Protein ID: WP_011233322.1
Location: 62519..63715 (1197 bp)
Type: Others
Protein ID: WP_011233324.1
Location: 63712..64752 (1041 bp)
Type: Others
Protein ID: WP_011233325.1
Location: 58824..59234 (411 bp)
Type: Others
Protein ID: WP_011233320.1
Location: 61911..62420 (510 bp)
Type: Others
Protein ID: WP_011233323.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K734_RS0026055329..56225+897WP_011233317.1LysR family transcriptional regulator-
K734_RS0026557043..57585+543WP_011233318.1sigma-70 family RNA polymerase sigma factor-
K734_RS0027057575..58429+855WP_011233319.1hypothetical protein-
K734_RS0027558824..59234-411WP_011233320.1helix-turn-helix transcriptional regulator-
K734_RS0028059394..59717+324WP_081423212.1type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein-
K734_RS0028560107..60379+273WP_011233321.1helix-turn-helix domain-containing proteinAntitoxin
K734_RS0029060379..61692+1314WP_011233322.1type II toxin-antitoxin system HipA family toxinToxin
K734_RS0029561911..62420-510WP_011233323.1helix-turn-helix transcriptional regulator-
K734_RS0030062519..63715+1197WP_011233324.1TolC family protein-
K734_RS0030563712..64752+1041WP_011233325.1membrane fusion-like protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-55)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49062.80 Da        Isoelectric Point: 6.1465

>T29508 WP_011233322.1 NC_021286:60379-61692 [Idiomarina loihiensis GSL 199]
MNTLDVYMNGYRVGHLSRNDSGAHTFRYDEMWIDKEGARPISLSMPLRHDAYSGREVINFFDNLLPDNEEVRDRIVARYQ
ADSDQAFDLLAAIGKDSVGALQFVPAGEKPGNIRELRYEKLTEEKLERVLKGYQSKAPLGMLRELDDFRISIAGAQEKTA
LLKIDGAWCIPNGNTPTTHIIKLPIGKIQSHDHTIDLSDSVENEMLCLKIARAFGFEAPDCEVIITPNVKALAIERFDRT
YSSDHSWLMRLPQEDYCQVLGLPSARKYESDNGPSIASIMKHLQGSADSTGDREAFMGAQVLFFLLGATDGHGKNFSVHI
EPYGAFRLTPLYDIISAYTAVGGTGINIRDLRLAMSLRGAGGKKRNIYQIFKRHFLNAAKEAEFSPTRMSEIINALCDQV
DDVIERVKGDLPNDFPTRVSTPIFDGMQERKRRLLIE

Download         Length: 1314 bp

>T29508 NC_021286:60379-61692 [Idiomarina loihiensis GSL 199]
ATGAATACGCTCGACGTCTATATGAACGGCTACCGCGTAGGTCACCTGAGTCGAAATGATTCCGGCGCTCACACATTTCG
TTATGATGAGATGTGGATTGATAAAGAGGGTGCACGGCCAATCTCTTTGTCTATGCCCTTACGCCATGACGCTTATTCAG
GGCGCGAGGTTATTAACTTTTTTGATAACCTGCTGCCTGACAATGAGGAAGTTAGAGACCGGATTGTTGCCCGTTATCAA
GCCGACTCCGATCAAGCATTTGATCTACTGGCGGCTATTGGGAAAGATAGTGTTGGTGCATTGCAGTTCGTCCCGGCAGG
AGAAAAACCAGGGAATATTCGTGAACTGCGTTATGAAAAACTCACCGAAGAGAAGTTAGAACGTGTTTTAAAAGGCTACC
AGTCCAAGGCACCTTTGGGCATGCTTCGGGAGTTGGATGATTTTAGAATATCAATTGCTGGGGCTCAGGAAAAAACAGCC
CTGTTAAAAATAGATGGTGCATGGTGTATTCCAAATGGAAACACGCCGACTACTCATATCATTAAACTTCCGATTGGTAA
GATTCAAAGCCACGATCACACAATCGATTTAAGTGACAGCGTTGAAAATGAAATGCTCTGCTTAAAAATTGCACGAGCAT
TCGGTTTTGAAGCACCGGATTGTGAGGTAATTATCACACCAAATGTTAAAGCCCTCGCCATTGAGCGTTTTGATCGTACA
TATTCAAGTGATCATTCTTGGTTAATGCGGCTTCCTCAAGAAGATTATTGTCAGGTGCTTGGACTGCCATCTGCGCGAAA
GTACGAATCGGATAACGGTCCGTCGATTGCCAGTATTATGAAGCATCTTCAAGGGTCTGCTGATTCCACAGGTGATCGTG
AGGCTTTCATGGGCGCACAGGTGCTTTTCTTTCTATTAGGCGCCACTGATGGGCACGGAAAGAATTTCTCTGTGCATATT
GAGCCTTATGGGGCTTTCCGTTTAACGCCTTTGTACGACATTATTTCTGCTTATACTGCTGTGGGTGGAACAGGCATCAA
TATTCGCGACTTGAGACTTGCGATGAGCTTGCGAGGGGCGGGGGGTAAAAAGCGGAACATCTATCAAATTTTTAAACGTC
ATTTTTTAAACGCAGCGAAAGAAGCTGAATTCAGTCCGACCAGAATGAGTGAAATTATCAACGCCCTGTGTGATCAGGTT
GACGATGTTATTGAACGAGTAAAAGGCGATTTACCCAATGATTTCCCGACAAGGGTTTCGACACCAATCTTTGATGGTAT
GCAAGAGCGGAAACGCCGACTACTTATCGAATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10291.87 Da        Isoelectric Point: 8.5607

>AT29508 WP_011233321.1 NC_021286:60107-60379 [Idiomarina loihiensis GSL 199]
MKITDPKALSIYLRDERRRRGLSQAKVGDLVGLRQGTVSKFESMPEKMQLDTLFRLLSALELELEVKPKGTVLKKNVDSS
TPGDEWTEEW

Download         Length: 273 bp

>AT29508 NC_021286:60107-60379 [Idiomarina loihiensis GSL 199]
ATGAAAATTACTGATCCCAAAGCATTATCGATCTACCTACGGGATGAACGAAGACGTCGCGGCCTGAGTCAAGCTAAGGT
TGGTGATTTAGTCGGACTTAGGCAGGGGACGGTCTCTAAGTTTGAATCAATGCCAGAGAAAATGCAGCTCGATACGTTGT
TTCGCTTGCTGTCCGCTTTAGAGCTCGAGCTGGAAGTGAAACCTAAAGGCACCGTTCTGAAGAAGAACGTTGATTCGTCA
ACGCCTGGTGATGAATGGACTGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ5QZX8

Antitoxin

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Source
ID
Structure
No matching records found

References