Detailed information of TA system TA029508

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 60107..61692
• Replicon: chromosome
• Accession: NC_021286
• Organism: Idiomarina loihiensis GSL 199

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q5QZX8
• Locus tag: K734_RS00290
• Protein ID: WP_011233322.1
• Coordinates: 60379..61692 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K734_RS00285
• Protein ID: WP_011233321.1
• Coordinates: 60107..60379 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K734_RS00260	55329..56225	+	897	WP_011233317.1	LysR family transcriptional regulator	-
K734_RS00265	57043..57585	+	543	WP_011233318.1	sigma-70 family RNA polymerase sigma factor	-
K734_RS00270	57575..58429	+	855	WP_011233319.1	hypothetical protein	-
K734_RS00275	58824..59234	-	411	WP_011233320.1	helix-turn-helix transcriptional regulator	-
K734_RS00280	59394..59717	+	324	WP_081423212.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
K734_RS00285	60107..60379	+	273	WP_011233321.1	helix-turn-helix domain-containing protein	Antitoxin
K734_RS00290	60379..61692	+	1314	WP_011233322.1	type II toxin-antitoxin system HipA family toxin	Toxin
K734_RS00295	61911..62420	-	510	WP_011233323.1	helix-turn-helix transcriptional regulator	-
K734_RS00300	62519..63715	+	1197	WP_011233324.1	TolC family protein	-
K734_RS00305	63712..64752	+	1041	WP_011233325.1	membrane fusion-like protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-55)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49062.80 Da
• Isoelectric Point: 6.1465

>T29508 WP_011233322.1 NC_021286:60379-61692 [Idiomarina loihiensis GSL 199]
MNTLDVYMNGYRVGHLSRNDSGAHTFRYDEMWIDKEGARPISLSMPLRHDAYSGREVINFFDNLLPDNEEVRDRIVARYQ
ADSDQAFDLLAAIGKDSVGALQFVPAGEKPGNIRELRYEKLTEEKLERVLKGYQSKAPLGMLRELDDFRISIAGAQEKTA
LLKIDGAWCIPNGNTPTTHIIKLPIGKIQSHDHTIDLSDSVENEMLCLKIARAFGFEAPDCEVIITPNVKALAIERFDRT
YSSDHSWLMRLPQEDYCQVLGLPSARKYESDNGPSIASIMKHLQGSADSTGDREAFMGAQVLFFLLGATDGHGKNFSVHI
EPYGAFRLTPLYDIISAYTAVGGTGINIRDLRLAMSLRGAGGKKRNIYQIFKRHFLNAAKEAEFSPTRMSEIINALCDQV
DDVIERVKGDLPNDFPTRVSTPIFDGMQERKRRLLIE

Nucleotide

• Length: 1314 bp

>T29508 NC_021286:60379-61692 [Idiomarina loihiensis GSL 199]
ATGAATACGCTCGACGTCTATATGAACGGCTACCGCGTAGGTCACCTGAGTCGAAATGATTCCGGCGCTCACACATTTCG
TTATGATGAGATGTGGATTGATAAAGAGGGTGCACGGCCAATCTCTTTGTCTATGCCCTTACGCCATGACGCTTATTCAG
GGCGCGAGGTTATTAACTTTTTTGATAACCTGCTGCCTGACAATGAGGAAGTTAGAGACCGGATTGTTGCCCGTTATCAA
GCCGACTCCGATCAAGCATTTGATCTACTGGCGGCTATTGGGAAAGATAGTGTTGGTGCATTGCAGTTCGTCCCGGCAGG
AGAAAAACCAGGGAATATTCGTGAACTGCGTTATGAAAAACTCACCGAAGAGAAGTTAGAACGTGTTTTAAAAGGCTACC
AGTCCAAGGCACCTTTGGGCATGCTTCGGGAGTTGGATGATTTTAGAATATCAATTGCTGGGGCTCAGGAAAAAACAGCC
CTGTTAAAAATAGATGGTGCATGGTGTATTCCAAATGGAAACACGCCGACTACTCATATCATTAAACTTCCGATTGGTAA
GATTCAAAGCCACGATCACACAATCGATTTAAGTGACAGCGTTGAAAATGAAATGCTCTGCTTAAAAATTGCACGAGCAT
TCGGTTTTGAAGCACCGGATTGTGAGGTAATTATCACACCAAATGTTAAAGCCCTCGCCATTGAGCGTTTTGATCGTACA
TATTCAAGTGATCATTCTTGGTTAATGCGGCTTCCTCAAGAAGATTATTGTCAGGTGCTTGGACTGCCATCTGCGCGAAA
GTACGAATCGGATAACGGTCCGTCGATTGCCAGTATTATGAAGCATCTTCAAGGGTCTGCTGATTCCACAGGTGATCGTG
AGGCTTTCATGGGCGCACAGGTGCTTTTCTTTCTATTAGGCGCCACTGATGGGCACGGAAAGAATTTCTCTGTGCATATT
GAGCCTTATGGGGCTTTCCGTTTAACGCCTTTGTACGACATTATTTCTGCTTATACTGCTGTGGGTGGAACAGGCATCAA
TATTCGCGACTTGAGACTTGCGATGAGCTTGCGAGGGGCGGGGGGTAAAAAGCGGAACATCTATCAAATTTTTAAACGTC
ATTTTTTAAACGCAGCGAAAGAAGCTGAATTCAGTCCGACCAGAATGAGTGAAATTATCAACGCCCTGTGTGATCAGGTT
GACGATGTTATTGAACGAGTAAAAGGCGATTTACCCAATGATTTCCCGACAAGGGTTTCGACACCAATCTTTGATGGTAT
GCAAGAGCGGAAACGCCGACTACTTATCGAATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10291.87 Da
• Isoelectric Point: 8.5607

>AT29508 WP_011233321.1 NC_021286:60107-60379 [Idiomarina loihiensis GSL 199]
MKITDPKALSIYLRDERRRRGLSQAKVGDLVGLRQGTVSKFESMPEKMQLDTLFRLLSALELELEVKPKGTVLKKNVDSS
TPGDEWTEEW

Nucleotide

• Length: 273 bp

>AT29508 NC_021286:60107-60379 [Idiomarina loihiensis GSL 199]
ATGAAAATTACTGATCCCAAAGCATTATCGATCTACCTACGGGATGAACGAAGACGTCGCGGCCTGAGTCAAGCTAAGGT
TGGTGATTTAGTCGGACTTAGGCAGGGGACGGTCTCTAAGTTTGAATCAATGCCAGAGAAAATGCAGCTCGATACGTTGT
TTCGCTTGCTGTCCGCTTTAGAGCTCGAGCTGGAAGTGAAACCTAAAGGCACCGTTCTGAAGAAGAACGTTGATTCGTCA
ACGCCTGGTGATGAATGGACTGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: Q5QZX8