Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2302301..2303335 | Replicon | chromosome |
| Accession | NZ_OW011623 | ||
| Organism | Thauera sp. PIV-1 strain Piv1 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | QM552_RS10510 | Protein ID | WP_282810229.1 |
| Coordinates | 2302301..2302870 (-) | Length | 190 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | QM552_RS10515 | Protein ID | WP_282810230.1 |
| Coordinates | 2302874..2303335 (-) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QM552_RS10495 (C4PIVTH_2181) | 2298157..2299503 | - | 1347 | WP_282810228.1 | hypothetical protein | - |
| QM552_RS10500 (C4PIVTH_2182) | 2299555..2299782 | - | 228 | WP_038011770.1 | hypothetical protein | - |
| QM552_RS10505 (C4PIVTH_2184) | 2300239..2301591 | - | 1353 | WP_156480721.1 | group II intron reverse transcriptase/maturase | - |
| QM552_RS10510 (C4PIVTH_2186) | 2302301..2302870 | - | 570 | WP_282810229.1 | PIN domain-containing protein | Toxin |
| QM552_RS10515 (C4PIVTH_2187) | 2302874..2303335 | - | 462 | WP_282810230.1 | helix-turn-helix domain-containing protein | Antitoxin |
| QM552_RS10520 (C4PIVTH_2188) | 2303649..2304995 | - | 1347 | WP_282810231.1 | McrC family protein | - |
| QM552_RS10525 (C4PIVTH_2189) | 2305010..2307391 | - | 2382 | WP_282810232.1 | AAA family ATPase | - |
| QM552_RS10530 (C4PIVTH_2190) | 2307397..2308089 | - | 693 | WP_282810233.1 | SprT family zinc-dependent metalloprotease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2300239..2325922 | 25683 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 190 a.a. Molecular weight: 21796.13 Da Isoelectric Point: 5.0483
>T295077 WP_282810229.1 NZ_OW011623:c2302870-2302301 [Thauera sp. PIV-1]
MTSFTVVYDACVLYPAPLRDLLMHLAMTDLFRAKWTDLIHAEWMRNVQKNRPDLTAEQLERTRLLMDAHVRDCLVHGYEY
LIPCLELPDPNDRHVLAAAIRSQSSVVVTFNLKDFPPESLAPYEIEAQHPDEFISDLIDLNPSQVLEAVRRCRSALKHPP
MTQDEYLDCLLRQGLPETVGLLRQWAIAF
MTSFTVVYDACVLYPAPLRDLLMHLAMTDLFRAKWTDLIHAEWMRNVQKNRPDLTAEQLERTRLLMDAHVRDCLVHGYEY
LIPCLELPDPNDRHVLAAAIRSQSSVVVTFNLKDFPPESLAPYEIEAQHPDEFISDLIDLNPSQVLEAVRRCRSALKHPP
MTQDEYLDCLLRQGLPETVGLLRQWAIAF
Download Length: 570 bp
Antitoxin
Download Length: 154 a.a. Molecular weight: 17017.32 Da Isoelectric Point: 5.2278
>AT295077 WP_282810230.1 NZ_OW011623:c2303335-2302874 [Thauera sp. PIV-1]
MMNTTVRPDLPTAEEVTLARESSRLLSLYLSSQDESQSIRVIDAAGEHEAVRLPTAAYRLLIDILSEMAQGNAVSLIPVH
AELTTQEAADMLNVSRPHLVKLLDGGTIPFHKVGTHRRVYYQDLVSYKNRIDADRTKALEELAAQAQELNMGY
MMNTTVRPDLPTAEEVTLARESSRLLSLYLSSQDESQSIRVIDAAGEHEAVRLPTAAYRLLIDILSEMAQGNAVSLIPVH
AELTTQEAADMLNVSRPHLVKLLDGGTIPFHKVGTHRRVYYQDLVSYKNRIDADRTKALEELAAQAQELNMGY
Download Length: 462 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|