Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 300518..301186 Replicon chromosome
Accession NZ_OV996158
Organism Enterococcus mundtii strain P2005

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N7O26_RS01405 Protein ID WP_108145382.1
Coordinates 300518..300691 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N7O26_RS01410 Protein ID WP_108145381.1
Coordinates 300731..301186 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7O26_RS01385 296635..297714 + 1080 WP_104775574.1 prephenate dehydrogenase -
N7O26_RS01390 297719..299002 + 1284 WP_260697330.1 3-phosphoshikimate 1-carboxyvinyltransferase -
N7O26_RS01395 299002..299508 + 507 WP_019722393.1 shikimate kinase -
N7O26_RS01400 299505..300371 + 867 WP_108145383.1 prephenate dehydratase -
N7O26_RS01405 300518..300691 + 174 WP_108145382.1 type II toxin-antitoxin system HicA family toxin Toxin
N7O26_RS01410 300731..301186 + 456 WP_108145381.1 hypothetical protein Antitoxin
N7O26_RS01415 301311..301820 + 510 WP_010736264.1 type 1 glutamine amidotransferase domain-containing protein -
N7O26_RS01420 301908..303104 - 1197 WP_260697331.1 galactokinase -
N7O26_RS01425 303101..304141 - 1041 WP_108145379.1 aldose epimerase family protein -
N7O26_RS01430 304369..305274 + 906 WP_010736261.1 AraC family transcriptional regulator -
N7O26_RS01435 305343..306020 + 678 WP_010736260.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-56)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6110.47 Da        Isoelectric Point: 11.5522

>T295072 WP_108145382.1 NZ_OV996158:300518-300691 [Enterococcus mundtii]
MPMTQQEMVKLLISIGGLKVKGGKGSHIKVKLPGVNRPIIVPSKLPKGTEHAILRQG

Download         Length: 174 bp

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16761.90 Da        Isoelectric Point: 3.9297

>AT295072 WP_108145381.1 NZ_OV996158:300731-301186 [Enterococcus mundtii]
MLVSYPALFYLETSEGYDSGFSVFFPDFPEMAGTSGSDIPEALENASDYLGILLAAEIEEDRTLPEPSLISSLSLIENNP
FKSDSEFILEYDSEKSFISMVAVDLTEYLGSEEPVKKTLTIPKWADKLGKEMHLNFSKTLTEAIVREKLGA

Download         Length: 456 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References