Detailed information of TA system TA029507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 2055129..2055640
• Replicon: chromosome
• Accession: NC_021281
• Organism: Fusobacterium nucleatum subsp. animalis 4 8

Toxin (Protein)

• Gene name: relB
• Uniprot ID: F7L0U8
• Locus tag: HMPREF0409_RS09775
• Protein ID: WP_005910516.1
• Coordinates: 2055129..2055383 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: F7L0U9
• Locus tag: HMPREF0409_RS09780
• Protein ID: WP_005910514.1
• Coordinates: 2055383..2055640 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF0409_RS09760	2052340..2052810	-	471	Protein_1913	ShlB/FhaC/HecB family hemolysin secretion/activation protein	-
HMPREF0409_RS09765	2052962..2053699	-	738	WP_008798883.1	tRNA pseudouridine(38-40) synthase TruA	-
HMPREF0409_RS09770	2053932..2055008	-	1077	WP_008798882.1	DHH family phosphoesterase	-
HMPREF0409_RS09775	2055129..2055383	-	255	WP_005910516.1	Txe/YoeB family addiction module toxin	Toxin
HMPREF0409_RS09780	2055383..2055640	-	258	WP_005910514.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HMPREF0409_RS09785	2055760..2056836	-	1077	WP_008798881.1	glycerophosphodiester phosphodiesterase	-
HMPREF0409_RS09790	2056875..2057873	-	999	WP_016340088.1	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	-
HMPREF0409_RS09795	2057900..2058373	-	474	WP_005910511.1	OmpH family outer membrane protein	-
HMPREF0409_RS09800	2058414..2060507	-	2094	WP_005910510.1	outer membrane protein assembly factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10007.42 Da
• Isoelectric Point: 8.0154

>T29507 WP_005910516.1 NC_021281:c2055383-2055129 [Fusobacterium nucleatum subsp. animalis 4_8]
MLLTWTDFAWEQYEELQEKDKRLVKKINTLIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKISDTQITIVAC
ANHY

Nucleotide

• Length: 255 bp

>T29507 NC_021281:c2055383-2055129 [Fusobacterium nucleatum subsp. animalis 4_8]
ATGTTATTGACTTGGACTGATTTTGCTTGGGAACAATATGAAGAATTACAAGAAAAAGATAAAAGACTTGTAAAAAAGAT
AAATACACTTATTAAGGATATCAAAAGAAATGGTAATGAAGGAATAGGAAAACCAGAACCTTTACAACATGAACTAAGTG
GTTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTTTATAAAATATCAGATACTCAAATAACAATAGTTGCTTGT
GCAAATCATTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10140.41 Da
• Isoelectric Point: 4.7022

>AT29507 WP_005910514.1 NC_021281:c2055640-2055383 [Fusobacterium nucleatum subsp. animalis 4_8]
MIATNYSEVRNNLKTYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQRLVESIKEAEKGNVKEHD
LIEVD

Nucleotide

• Length: 258 bp

>AT29507 NC_021281:c2055640-2055383 [Fusobacterium nucleatum subsp. animalis 4_8]
ATGATAGCAACAAATTATTCAGAGGTTAGAAATAATTTAAAAACTTATTGTGATAAGGCAACAAAGGACTATGAAACTAT
AATTATTACAAGAAAAAATAATGAAAATGTTGTTTTAATGAGTGAAGAAGAATATAACAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAGACTTGTAGAAAGTATAAAAGAAGCTGAAAAGGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA

Structures

Toxin

• AlphaFold DB: F7L0U8

Antitoxin

• AlphaFold DB: F7L0U9