Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1704065..1704563 Replicon chromosome
Accession NZ_OV904788
Organism Streptococcus pneumoniae strain RMV7 isolate RMV7domi

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MMH06_RS08760 Protein ID WP_001812387.1
Coordinates 1704065..1704319 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag MMH06_RS08765 Protein ID WP_000208080.1
Coordinates 1704321..1704563 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMH06_RS08745 (IONPJBJN_01736) 1700288..1701274 + 987 WP_000204727.1 L-lactate dehydrogenase -
MMH06_RS08750 (IONPJBJN_01737) 1701583..1702929 + 1347 WP_001814919.1 IS1380-like element ISSpn5 family transposase -
MMH06_RS08755 (IONPJBJN_01738) 1703245..1704018 - 774 WP_000731129.1 ion channel -
MMH06_RS08760 (IONPJBJN_01739) 1704065..1704319 - 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MMH06_RS08765 (IONPJBJN_01740) 1704321..1704563 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
MMH06_RS08770 (IONPJBJN_01741) 1704654..1705463 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
MMH06_RS08775 (IONPJBJN_01742) 1705465..1706814 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
MMH06_RS08780 (IONPJBJN_01743) 1706807..1707511 - 705 WP_000722076.1 response regulator YycF -
MMH06_RS08785 (IONPJBJN_01744) 1707566..1708741 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1701583..1702929 1346


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.85 Da        Isoelectric Point: 10.7632

>T295069 WP_001812387.1 NZ_OV904788:c1704319-1704065 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT295069 WP_000208080.1 NZ_OV904788:c1704563-1704321 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References