Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 998657..999325 Replicon chromosome
Accession NZ_OV904788
Organism Streptococcus pneumoniae strain RMV7 isolate RMV7domi

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag MMH06_RS05335 Protein ID WP_001132282.1
Coordinates 998657..998836 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag MMH06_RS05340 Protein ID WP_000961810.1
Coordinates 998873..999325 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMH06_RS05310 (IONPJBJN_01042) 994530..995849 + 1320 WP_000502563.1 glycoside hydrolase family 32 protein -
MMH06_RS05320 (IONPJBJN_01044) 996396..997667 - 1272 WP_001113206.1 replication-associated recombination protein A -
MMH06_RS05325 (IONPJBJN_01045) 997937..998176 + 240 WP_000818079.1 hypothetical protein -
MMH06_RS05330 998341..998520 + 180 WP_001048906.1 hypothetical protein -
MMH06_RS05335 (IONPJBJN_01046) 998657..998836 + 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
MMH06_RS05340 (IONPJBJN_01047) 998873..999325 + 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MMH06_RS05345 (IONPJBJN_01048) 999616..1000086 + 471 WP_000257114.1 DUF3013 family protein -
MMH06_RS05350 (IONPJBJN_01049) 1000105..1001193 + 1089 WP_000719711.1 site-2 protease family protein -
MMH06_RS05355 (IONPJBJN_01050) 1001174..1001308 + 135 Protein_1013 7,8-dihydro-8-oxoguanine-triphosphatase -
MMH06_RS05360 (IONPJBJN_01051) 1001442..1002476 + 1035 WP_000747915.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T295068 WP_001132282.1 NZ_OV904788:998657-998836 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT295068 WP_000961810.1 NZ_OV904788:998873-999325 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References