Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4904171..4905852 Replicon chromosome
Accession NZ_OV754010
Organism Klebsiella pneumoniae isolate BB1541

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag O0V11_RS23940 Protein ID WP_019724882.1
Coordinates 4904171..4905088 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag O0V11_RS23945 Protein ID WP_004177809.1
Coordinates 4905094..4905852 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0V11_RS23920 (VKR_04700) 4899477..4900997 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
O0V11_RS23925 (VKR_04701) 4900994..4901992 + 999 WP_002885172.1 ribose ABC transporter permease -
O0V11_RS23930 (VKR_04702) 4902023..4902964 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
O0V11_RS23935 (VKR_04703) 4903039..4904046 + 1008 WP_015959270.1 carbohydrate kinase family protein -
O0V11_RS23940 (VKR_04704) 4904171..4905088 - 918 WP_019724882.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
O0V11_RS23945 (VKR_04705) 4905094..4905852 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
O0V11_RS23950 (VKR_04706) 4905938..4906666 - 729 WP_002885152.1 response regulator transcription factor -
O0V11_RS23955 (VKR_04708) 4906939..4909086 + 2148 WP_267924524.1 formate dehydrogenase subunit alpha -
O0V11_RS23960 (VKR_04709) 4909316..4910002 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T295065 WP_019724882.1 NZ_OV754010:c4905088-4904171 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT295065 WP_004177809.1 NZ_OV754010:c4905852-4905094 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YLF8

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References