Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4740938..4741454 Replicon chromosome
Accession NZ_OV754010
Organism Klebsiella pneumoniae isolate BB1541

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag O0V11_RS23125 Protein ID WP_004178374.1
Coordinates 4740938..4741222 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag O0V11_RS23130 Protein ID WP_002886901.1
Coordinates 4741212..4741454 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0V11_RS23100 (VKR_04541) 4736355..4736618 - 264 WP_025987940.1 PTS sugar transporter subunit IIB -
O0V11_RS23105 4736748..4736921 + 174 WP_019725541.1 hypothetical protein -
O0V11_RS23110 (VKR_04542) 4736924..4737667 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
O0V11_RS23115 (VKR_04543) 4738024..4740162 + 2139 WP_019725540.1 anaerobic ribonucleoside-triphosphate reductase -
O0V11_RS23120 (VKR_04544) 4740470..4740934 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
O0V11_RS23125 (VKR_04545) 4740938..4741222 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O0V11_RS23130 (VKR_04546) 4741212..4741454 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
O0V11_RS23135 (VKR_04547) 4741532..4743442 - 1911 WP_019725539.1 PRD domain-containing protein -
O0V11_RS23140 (VKR_04548) 4743465..4744619 - 1155 WP_004178372.1 lactonase family protein -
O0V11_RS23145 (VKR_04549) 4744686..4745426 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T295064 WP_004178374.1 NZ_OV754010:c4741222-4740938 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT295064 WP_002886901.1 NZ_OV754010:c4741454-4741212 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References