Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4660849..4661540 Replicon chromosome
Accession NZ_OV754010
Organism Klebsiella pneumoniae isolate BB1541

Toxin (Protein)


Gene name ykfI Uniprot ID A0A483YFJ1
Locus tag O0V11_RS22790 Protein ID WP_025987721.1
Coordinates 4660849..4661190 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A2A5MHA6
Locus tag O0V11_RS22795 Protein ID WP_019725272.1
Coordinates 4661214..4661540 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0V11_RS22775 (VKR_04477) 4657808..4659043 - 1236 WP_124044824.1 hypothetical protein -
O0V11_RS22780 (VKR_04478) 4659503..4659874 - 372 WP_223369725.1 hypothetical protein -
O0V11_RS22785 (VKR_04479) 4659901..4660734 - 834 WP_025987720.1 DUF4942 domain-containing protein -
O0V11_RS22790 (VKR_04480) 4660849..4661190 - 342 WP_025987721.1 TA system toxin CbtA family protein Toxin
O0V11_RS22795 (VKR_04481) 4661214..4661540 - 327 WP_019725272.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
O0V11_RS22800 (VKR_04482) 4661554..4662030 - 477 WP_019725273.1 DNA repair protein RadC -
O0V11_RS22805 (VKR_04483) 4662040..4662486 - 447 WP_025987722.1 antirestriction protein -
O0V11_RS22810 (VKR_04484) 4662698..4663387 - 690 WP_009309812.1 hypothetical protein -
O0V11_RS22815 (VKR_04485) 4663952..4664842 - 891 WP_019725276.1 YfjP family GTPase -
O0V11_RS22820 (VKR_04486) 4664925..4666013 - 1089 WP_019725277.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4643767..4682688 38921


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12867.90 Da        Isoelectric Point: 8.5195

>T295063 WP_025987721.1 NZ_OV754010:c4661190-4660849 [Klebsiella pneumoniae]
MKTLPATIQRAAKPCPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQATGLLRQRHLPSIR

Download         Length: 342 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12276.01 Da        Isoelectric Point: 6.9560

>AT295063 WP_019725272.1 NZ_OV754010:c4661540-4661214 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YFJ1

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MHA6

References