Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2656273..2657861 Replicon chromosome
Accession NZ_OV754010
Organism Klebsiella pneumoniae isolate BB1541

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag O0V11_RS13070 Protein ID WP_002904792.1
Coordinates 2656273..2657595 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag O0V11_RS13075 Protein ID WP_002904790.1
Coordinates 2657595..2657861 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0V11_RS13055 (VKR_02569) 2651329..2653830 + 2502 WP_064145444.1 fimbria/pilus outer membrane usher protein -
O0V11_RS13060 (VKR_02570) 2653818..2654822 + 1005 WP_064145446.1 fimbrial protein -
O0V11_RS13065 (VKR_02571) 2654964..2656256 + 1293 WP_064145447.1 glycoside hydrolase family 10 protein -
O0V11_RS13070 (VKR_02572) 2656273..2657595 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
O0V11_RS13075 (VKR_02573) 2657595..2657861 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
O0V11_RS13080 (VKR_02574) 2658249..2658575 - 327 WP_002904788.1 hydroxyisourate hydrolase -
O0V11_RS13085 (VKR_02575) 2658572..2659072 - 501 WP_064145448.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
O0V11_RS13090 (VKR_02576) 2659050..2660429 - 1380 WP_064145449.1 nucleobase:cation symporter-2 family protein -
O0V11_RS13095 (VKR_02577) 2660775..2661929 + 1155 WP_023282572.1 FAD-dependent urate hydroxylase HpxO -
O0V11_RS13100 (VKR_02578) 2661910..2662833 - 924 WP_064145450.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T295060 WP_002904792.1 NZ_OV754010:c2657595-2656273 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT295060 WP_002904790.1 NZ_OV754010:c2657861-2657595 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References